![]() We review the latest developments for labelling and functionalizing proteins with small localization and functionalized reporters. These instrumentation-based innovations have occurred in parallel with the development of new molecular approaches to label protein targets, to evolve new biosensors and to target them to appropriate cell types or subcellular compartments. Super-resolution microscopy and tissue imaging approaches have recently exploded. Over the last few decades, the development of advanced imaging methods has revolutionized our approach to explore the brain. Neuroscientists have often been at the forefront of technological and methodological developments to overcome these hurdles to visualize, quantify and modify cell and network properties. ![]() The branched and extended morphology of nerve cells, their subcellular complexity, the multiplicity of brain cell types as well as their intricate connectivity and the scattering properties of brain tissue present formidable challenges to the understanding of brain function. The brain is arguably the most complex organ. ![]()
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